How polypharmacy led to 43 prescription tablets at once


Polypharmacy or the use of multiple drugs is common in the elderly. While 89% of people aged 65 and over take at least one prescription drug, 54% take four or more.1 Data from Merck similarly found that nearly 80% of older people regularly take at least two prescription drugs, while 36% regularly use five or more different drugs – and this does not include over-the-counter drugs.2

Adverse effects of polypharmacy are common and may lead patients to seek more and more medications to treat side effects caused by an unsafe medication regimen. It is a vicious circle, one perpetuated by a broken health system that revolves around pharmaceutically guided, fragmented care.

Not only do many patients visit multiple doctors, each of whom can prescribe their own set of medications, but patients can put pressure on physicians to prescribe medications they have seen in advertisements directly to consumers. Instead of looking at the bigger picture of how to become healthy, taking into account essential factors such as diet, stress, and physical activity, “health care” for the elderly often turns into “drug care,” with potentially disastrous results.

One patient – 43 prescription drugs

A comment by Dr. Mark E. Williams published on Medscape highlights how extreme polypharmacy can become. In some cases, it was not just four or five drugs, but dozens of them, and in the case of Williams’ Allison patient, it was 43. The woman was transferred to a chronic care facility for long-term care. to bipolar disease.

She had been treated in hospital a few days earlier for mental health problems, which Williams said was “probably linked to inappropriate polypharmacy”.3

“Despite being admitted to the hospital for side effects related to polypharmacy, Allison was discharged to my facility for 43 prescription drugs and almost the same number of over-the-counter (OTC) drugs. It took the nurse more than 10 minutes to review the medication on the phone with me, ”he wrote.4

Allison’s symptoms included fatigue, dizziness, muscle aches, headaches, nausea, insomnia and more, and she sought additional medication to treat them. Not only was the woman taking duplicate medications designed to treat the same symptoms, but she was also taking medications designed to treat common side effects.

“The chemical broth in her body leads to mental and physical problems,” Williams told the patient’s daughter, but she too accepted the idea that more drugs equals better care. After overcoming the patient’s resistance to stopping medication, Williams managed to reduce Allison’s medication to about 15 over a three-month period – still a staggering number, but less than 43.

“Allison has improved, both mentally and physically,” Williams wrote.5 but challenges continued, including a patient demanding a memory drug she saw advertised on television, and an incident in which her daughter gave her help sleeping without a prescription, leading to lethargy, confusion and slurred speech.

Eventually, Allison was transferred to another facility, where dangerous polypharmacy undoubtedly continued. Although Williams’ comment highlights the extreme case, it is not unique – polypharmacy is prevalent among the elderly.

Polypharmacy worsens health

When drugs are prescribed in excessive amounts, including for the treatment of side effects of other drugs, the patient’s health suffers. “The use of many drugs can result in drug-related problems such as inappropriate indications, therapeutic duplication, adverse effects, drug interactions, unnecessary drugs, poor adherence, and pressure on health care resources,” according to an article in The Journal of Nursing.6

She also noted that polypharmacy is a preventable risk factor for hospitalization of the elderly due to drug side effects. Meanwhile, the risks of polypharmacy are well noted. Adverse outcomes including mortality, falls, drug side effects, prolonged hospital stays, and hospital admissions are listed in BMC geriatrics, and the risk of injury increases with the number of medications.7 According to the systematic review:8

“Damage can occur due to a multitude of factors, including drug-drug interactions and drug-disease interactions. Elderly patients are at even greater risk of side effects due to reduced kidney and liver function, lower lean body mass, reduced hearing, vision, cognition and mobility. ”

In 2007, Dr. Michael Stern, a geriatric emergency specialist at New York Presbyterian Hospital, even told a New York Times reporter that polypharmacy accounts for more than a quarter of all hospital admissions and would be considered the fifth leading cause of death if categorized.9

Older people are more sensitive to the side effects of medications

The fact that older people are more likely to take more prescription drugs is a double-edged sword, as older people are already at increased risk of drug side effects. In fact, the elderly are estimated to be twice as sensitive to drug side effects compared to younger people.

“Side effects are also likely to be more serious, affect quality of life and result in doctor visits and hospitalizations,” according to Merck’s handbook, which also explains several reasons why older people are so sensitive to drug side effects:10

  • Older people have less water and more body fat; this allows for higher concentrations of water-soluble drugs and increased accumulation of fat-soluble drugs
  • The kidneys are less effective in excreting drugs in the urine
  • The liver is less able to metabolize drugs, so they are not removed so easily from the body
  • “Older people are more likely to have chronic medical disorders that can be exacerbated by drugs or that can affect the way drugs work.”

Some common examples of how medications can affect the elderly differently include blood pressure medications, which can lead to more dramatic drops in the elderly, leading to symptoms of dizziness and falls. Older people can also become confused and sleepy when they use anti-anxiety medications, more than is usually seen in younger people. Such effects may be exacerbated only when multiple medications are taken at the same time.

In fact, due to the changes that occur during biological aging, it is now known that drugs need to be clinically tested especially with older adults in mind. However, older adults are often excluded from clinical trials, which means that the safety and efficacy of drugs in this population are often unknown, with no supporting evidence.

“Inevitably, this lack of evidence has often led to inadequate drug treatment and, consequently, to various detrimental clinical outcomes,” according to a review published in March 2021 in European Geriatric Medicine.11

Why are so many older people taking antidepressants?

Over-prescribing is widespread among the elderly population, and antidepressants are one such example. The last two decades have seen a large increase in the number of antidepressants being prescribed to the elderly, with no similar sharp increase in the number of depressants, according to a study published in The British Journal of Psychiatry.12

The findings suggest that the elderly may be over-prescribed antidepressants, which could have serious implications for their health, although scientists were reluctant to say so, noting instead: “We cannot conclude that older patients are being prescribed antidepressants unnecessarily.”13

In the first study group, 4.2% of adults were taking antidepressants, but this jumped to 10.7% in a later study. During this time, the prevalence of depression decreased, but only slightly, from 7.9% to 6.8%.14 It is also worth noting that among older adults living in nursing homes, the prevalence of depression remained unchanged, but antidepressant use increased from 7.4% to 29.2%.15

Several suggestions have been made as to why antidepressant prescribing rates have increased so sharply without a similar increase in depression, including overdiagnosis or prescribing medications for conditions other than depression. However, most prescribed antidepressants are not diagnosed with depression.

Furthermore, antidepressants carry a risk of side effects that could easily turn into multiple medications. For example, antidepressant users have an increased risk of developing type 2 diabetes,16 and the use of antidepressants is associated with thicker arteries, which could contribute to the risk of heart disease and stroke.17

Nearly half of those over the age of 75 take statins

Cholesterol lowering drugs statins are another example of a group of over-prescribed drugs that contribute to the risks of polypharmacy. In the United States, close to 50% of adults in the United States over the age of 75 take a statin,18 although their use can also harm brain health – more than doubling the risk of dementia in some cases.19

There is also a link between statins and diabetes, to the extent that people who take statins are twice as likely to be diagnosed with diabetes as those who do not, and those who take medication for more than two years are more than three times more likely to be diagnosed.20,21 With the diagnosis of diabetes, of course, comes more medication.

Statins are often unnecessary at all. Although they are effective in lowering cholesterol, whether this is a drug to avoid heart disease and prolong life is the subject of heated debate. A scientific review in 2018 presented significant evidence that high LDL and total cholesterol are not an indicator of heart disease risk and that statin therapy is of dubious benefit as a form of primary prevention for this reason.22

Drugs are not equally good health

Excessive prescribing of tablets leads the elderly into a downward spiral of increased side effects and deteriorating health. A holistic approach is needed, one that addresses the key principles of good health and creates true wellness instead of trying to mask symptoms with multiple pills.

As just one example, in a study of older people with depression, 80% experienced a significant reduction in depressive symptoms after 10 weeks of strength training, so the researchers concluded that exercise is “an effective antidepressant in older people with depression, and also improves strength. morality and quality of life. ”23

It is important to work with a doctor who understands the risks of polypharmacy and the fact that good health does not come from the pill. Only by building a health plan related to diet, exercise, sleep, emotional well-being and exposure to toxic substances, along with only targeted and truly needed medications and / or supplements, can you achieve optimal health.


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